Writing from his home in Toronto, Canada in 1987, John Wheelwright narrates the story of his childhood. Peppering his narrative with frequent diary entries in which he chronicles his outrage against the behavior of the Ronald Reagan administration in the late 1980s, Wheelright tells the story of his early life in Gravesend, New Hampshire, when his best friend was Owen Meany, who he remembers as the boy who accidentally killed Wheelwright's mother and made Wheelright believe in God. The narrative of A Prayer for Owen Meany does not follow a perfect chronology, as John pieces together the story he wants to tell.