In 2070, the Earth's weather is controlled from a base on the moon. But when the Doctor and his friends arrive, all is not well. They discover unexplainable drops of air pressure, minor problems with the weather control systems, and an outbreak of a mysterious plague.
With Jamie injured, and the members of the crew going missing, the Doctor realises that the moonbase is under attack. Some malevolent force is infecting the crew and sabotaging the systems as a prelude to an invasion on Earth. And the Doctor thinks he knows who is behind it: the Cybermen.