Two fallen angels (Matt Damon and Ben Affleck), sentenced to eternal exile in Wisconsin, are trying to get back into heaven. A renegade cardinal in New Jersey (George Carlin), as part of his "Catholicism Wow!" campaign, has opened a loophole in Catholic doctrine that would give them their opportunity-and, in proving God's judgment wrong, destroy the universe. An abortion clinic counselor (Linda Fiorentino) who may or may not be of holy bloodlines is tapped as the very reluctant savior-and, accompanied by the thirteenth apostle (Chris Rock), a wayward muse (Salma Hayek), and two very questionable prophets (Jason Mewes and Kevin Smith, AKA Jay and Silent Bob), she sets off on a mission to save the world.