Handbook of Design and Analysis of Experiments provides a detailed overview of the tools required for the optimal design of experiments and their analyses. The handbook gives a unified treatment of a wide range of topics, covering the latest developments. This carefully edited collection of 25 chapters in seven sections synthesizes the state of the art in the theory and applications of designed experiments and their analyses. Written by leading researchers in the field, the chapters offer a balanced blend of methodology and applications. The first section presents a historical look at experimental design and the fundamental theory of parameter estimation in linear models. The second section deals with settings such as response surfaces and block designs in which the response is modeled by a linear model, the third section covers designs with multiple factors (both treatment and blocking factors), and the fourth section presents optimal designs for generalized linear models, other nonlinear models, and spatial models. The fifth section addresses issues involved in designing various computer experiments. The sixth section explores "cross-cutting" issues relevant to all experimental designs, including robustness and algorithms. The final section illustrates the application of experimental design in recently developed areas. This comprehensive handbook equips new researchers with a broad understanding of the fields numerous techniques and applications. The book is also a valuable reference for more experienced research statisticians working in engineering and manufacturing, the basic sciences, and any discipline that depends on controlled experimental investigation.