Provides a conceptual overview of pathophysiology and mechanisms of disease, designed to ease the transition from the basic sciences to the clinical years. This book will be a phenomenal learning tool for students in the second and third years of medical school and during USMLE Step 1 preparation, but will also be very helpful to nurses, nurse practitioners, physician assistants, and other health care professonals seeking to learn or review the physiological mechanisms of diseases, their diagnosis, and their management. The accompanied CD, Differential Diagnosis, allows one to select a symptom, sign, or lab finding and see all of the many diseases that could cause it, classified by pathophysiological mechanism. By teaching basic medical science and clinical reasoning hand-in-hand in a simple, light, and highly accessible writing style, this book provides an integrated and easy-to-understand approach to learning the science of medicine.