The Adrenergic Receptors

Dianne M. Perez

Springer Science & Business Media

2020

404 páginas

13h 28m

ISBN-10: 1588294234

Inglês

This volume presents an authoritative review of the current state-of-the-art understanding of the structure and function of the adrenergic receptor subtypes, as well as of the role played by these receptors in physiological and pathophysiological settings. Topics range from structure-function studies and the imaging of adrenergic receptors to the use of genetically altered mouse models and pharmacogenomics. The side-by-side comparison of all the adrenergic receptors (a1, a2, and b) provides the reader with an excellent survey of the field, including the rationale for designing better drugs to control blood pressure and heart function. Contents: Part I: Historical Perspectives. Adrenergic Receptors: Historical Perspectives From the 20th Century. Part II: Structure-Function. Ligand Binding, Activation, and Agonist Trafficking. New Signal Transduction Paradigms. Regulation of the Cellular Localization and Trafficking of the Adrenergic Receptors. Adrenergic Receptors in Clinical Medicine. Part III: Imaging Adrenergic Receptors and Their Function. Use of Fluorescent Ligands and Receptors to Visualize Adrenergic Receptors. Localization of Adrenergic Receptor Subtypes and Transgenic Expression of Fluorescent-Tagged Receptors. Part IV: Genetically Altered Mouse Models. The 1-Adrenergic Receptors: Lessons From Knockout. The 2-Adrenergic Receptors: Lessons From Knockouts. The -Adrenergic Receptors: Lessons From Knockouts. Lessons From Overexpressed Mouse Models. Adrenergic Receptor Signaling Components in Gene Therapy. Part V: Pharmacogenomics. Genetic, Molecular, and Clinical Characterization of Adrenergic Receptor Polymorphisms. Microarray Analysis of Novel Adrenergic Receptor Functions. Part VI: Summary and Future Endeavors. Summary and Future Endeavors. Index.