This guide to the histological diagnosis of periprosthetic tissue pathologies in joint arthroplasty is intended to provide a concise, yet comprehensive introduction to the host soft tissue and bone reactions to implants and their wear particulate materials. It is also a practical aid for tissue sampling and processing for the optimal pathological analysis. The target audience comprises orthopedic surgeons, either in practice or in training, as well as clinicians, radiologists, pathologists, and biomechanical engineers who are interested in understanding the details of the histological examination and report.

